Acute lymphoblastic leukemia and developmental biology
نویسندگان
چکیده
منابع مشابه
Acute lymphoblastic leukemia: age and biology
Acute lymphoblastic leukemia (ALL) is the most frequent neoplasm in children, while being relatively rare in adults. The outcome of children with ALL is far superior than that observed in adults, whose survival rates generally do not exceed 40%. A retrospective analysis recently carried out on a large series of cases enrolled in the AIEOP and GIMEMA protocols for the treatment of pediatric and ...
متن کاملBiology and treatment of acute lymphoblastic leukemia.
Acute lymphoblastic leukemia (ALL), the most common type of cancer in children, is a heterogeneous disease in which many genetic lesions result in the development of multiple biologic subtypes. Today, with intensive multiagent chemotherapy, most children who have ALL are cured. The many national or institutional ALL therapy protocols in use tend to stratify patients in a multitude of different ...
متن کاملThe Biology of Acute Lymphoblastic Leukemia
Discoveries of the underlying biological pathways that drive leukemogenesis in children have taken place at an astonishing pace. These findings have resulted in large part because of the evolution of technical developments in analyzing chromosome structure, the development of monoclonal antibodies capable of recognizing discrete cell surface proteins that correlate with cell lineage and differe...
متن کاملThe biology and treatment of acute lymphoblastic leukemia in adults.
Despite reports to the contrary, only a small minority of adults with ALL are currently cured. Results have improved modestly with more intensive postremission chemotherapy and with tailoring of protocols in individuals with specific subsets of ALL. The use of growth factors may further improve treatment results. The performance of allogeneic BMT in first remission is clearly effective in some ...
متن کاملClinical and laboratory biology of childhood acute lymphoblastic leukemia.
A cute lymphoblastic leukemia (ALL) is the most common malignancy of childhood, accounting for 25% of cancers diagnosed in children and adolescents aged 1-19 years, and translating to approximately 3000 new cases diagnosed in the US yearly. Progress in therapy for childhood ALL has been dramatic, with event-free survival (EFS,meaning that patients do not relapse or succumb to side effects) impr...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2011
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.10.20.17779